Exploring threats to generalisability in a large international rehabilitation trial (AVERT)

J Bernhardt; A Raffelt; L Churilov; RI Lindley; S Speare; J Ancliffe; MA Katijjahbe; S Hameed; S Lennon; A McRae; D Tan; J Quiney; HC Williamson; J Collier; HM Dewey; GA Donnan; P Langhorne; AG Thrift

Journal article

Exploring threats to generalisability in a large international rehabilitation trial (AVERT)

J Bernhardt, A Raffelt, L Churilov, RI Lindley, S Speare, J Ancliffe, MA Katijjahbe, S Hameed, S Lennon, A McRae, D Tan, J Quiney, HC Williamson, J Collier, HM Dewey, GA Donnan, P Langhorne, AG Thrift

BMJ Open | BMJ PUBLISHING GROUP | Published : 2015

DOI: 10.1136/bmjopen-2015-008378

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Abstract

Objective: The purpose of this paper is to examine potential threats to generalisability of the results of a multicentre randomised controlled trial using data from A Very Early Rehabilitation Trial (AVERT). Design: AVERT is a prospective, parallel group, assessor-blinded randomised clinical trial. This paper presents data assessing the generalisability of AVERT. Setting: Acute stroke units at 44 hospitals in 8 countries. Participants: The first 20 000 patients screened for AVERT, of whom 1158 were recruited and randomised. Model: We use the Proximal Similarity Model, which considers the person, place, and setting and practice, as a framework for considering generalisability. As well as comp..

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University of Melbourne Researchers

Julie Bernhardt Author

Leonid Churilov Author

Geoffrey Donnan Author

Tissa Wijeratne Author

Related Projects (1)

AVERT: A large, international, randomised controlled trial testing efficacy and cost effectiveness of early and frequent mobilisation after stroke

AVERT is a large, international clinical trial that tests whether introducing early and frequent exercise helps reduce the unacceptably high..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This trial was funded through grants from: the National Health and Medical Research Council (project grant numbers: 386201, 1041401), the Stroke Association Australia, Chest Heart and Stroke Scotland (Res08/A114), and Sing Health (SHF/FG401P/2008). All involved researchers are independent of these funding bodies.